Tesa M Severson Selected Research

Neoplasms (Cancer)

11/2023	Grade Group 1 Prostate Cancers Exhibit Tumor-defining Androgen Receptor-driven Programs.
10/2023	PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription.
2/2023	Enhancer profiling identifies epigenetic markers of endocrine resistance and reveals therapeutic options for metastatic castration-resistant prostate cancer patients.
11/2022	Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.
1/2022	Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence.
1/2021	The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair.
1/2020	Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.
1/2020	The MSP-RON axis stimulates cancer cell growth in models of triple negative breast cancer.
12/2019	Cistrome Partitioning Reveals Convergence of Somatic Mutations and Risk Variants on Master Transcription Regulators in Primary Prostate Tumors.
1/2019	Lysine specific demethylase 1 inactivation enhances differentiation and promotes cytotoxic response when combined with all-trans retinoic acid in acute myeloid leukemia across subtypes.

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Tesa M Severson Research Topics

Disease

22	Neoplasms (Cancer) 11/2023 - 02/2010
9	Breast Neoplasms (Breast Cancer) 01/2020 - 01/2014
8	Prostatic Neoplasms (Prostate Cancer) 11/2023 - 01/2020
2	Hypersensitivity (Allergy) 01/2022 - 04/2018
2	Pathologic Complete Response 08/2017 - 01/2017
1	Lung Neoplasms (Lung Cancer) 10/2023
1	Acute Promyelocytic Leukemia 01/2019
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019
1	Squamous Cell Carcinoma of Head and Neck 04/2018
1	Male Breast Neoplasms (Male Breast Cancer) 01/2017
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2017
1	Non-Hodgkin Lymphoma (Lymphosarcoma) 07/2011
1	Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects 12/2010

Drug/Important Bio-Agent (IBA)

10	Androgen Receptors (Androgen Receptor)IBA 11/2023 - 01/2017
7	ChromatinIBA 11/2023 - 06/2016
5	DNA (Deoxyribonucleic Acid)IBA 04/2018 - 08/2015
4	Hormones (Hormone)IBA 01/2021 - 01/2017
3	Proteins (Proteins, Gene)FDA Link 11/2023 - 01/2014
3	Transcription Factors (Transcription Factor)IBA 11/2021 - 01/2020
3	Histones (Histone)IBA 01/2021 - 02/2010
3	Estrogen Receptor alphaIBA 01/2018 - 06/2016
3	Estrogen ReceptorsIBA 01/2018 - 01/2014
3	Tamoxifen FDA LinkGeneric 06/2016 - 01/2014
2	enzalutamideIBA 02/2023 - 01/2022
2	AndrogensIBA 01/2022 - 01/2021
2	NucleotidesIBA 01/2020 - 12/2019
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 04/2018 - 08/2017
2	SteroidsIBA 01/2018 - 01/2017
2	Progesterone Receptors (Progesterone Receptor)IBA 01/2018 - 01/2014
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 06/2016
1	Vorinostat FDA Link 02/2023
1	Histone Deacetylase InhibitorsIBA 02/2023
1	RNA (Ribonucleic Acid)IBA 01/2022
1	Factor V (Coagulation Factor V)IBA 11/2021
1	CCCTC-Binding FactorIBA 01/2021
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2020
1	LigandsIBA 01/2020
1	macrophage stimulating proteinIBA 01/2020
1	RON proteinIBA 01/2020
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2020
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 01/2019
1	GSK2879552IBA 01/2019
1	Cytostatic AgentsIBA 01/2019
1	Lysine (L-Lysine)FDA Link 01/2019
1	Mitomycin (Mitomycin-C)FDA LinkGeneric 04/2018
1	A 19IBA 04/2018
1	B7-H1 AntigenIBA 01/2018
1	Glucocorticoid Receptors (Glucocorticoid Receptor)IBA 01/2018
1	Poly (ADP-Ribose) Polymerase-1IBA 01/2017
1	veliparibIBA 01/2017
1	Carboplatin (JM8)FDA LinkGeneric 01/2017
1	OligonucleotidesIBA 08/2015
1	Insulin-Like PeptidesIBA 01/2014
1	TensinsIBA 01/2014
1	MTOR InhibitorsIBA 01/2014
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2014
1	TOR Serine-Threonine KinasesIBA 01/2014
1	human ERBB2 proteinIBA 01/2014
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2014
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 01/2014
1	SterolsIBA 12/2010
1	Histone MethyltransferasesIBA 02/2010

Therapy/Procedure

6	Therapeutics 01/2022 - 01/2014
2	Castration 02/2023 - 11/2021